Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.

doi:10.1016/j.neo.2016.07.006

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Article

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.

Neoplasia (New York, N.Y.) - 1 Sept 2016

Pitarresi Jason R, Liu Xin, Sharma Sudarshana M, Cuitiño Maria C, Kladney Raleigh D, Mace Thomas A, Donohue Sydney, Nayak Sunayana G, Qu Chunjing, Lee James, Woelke Sarah A, Trela Stefan, LaPak Kyle, Yu Lianbo, McElroy Joseph, Rosol Thomas J, Shakya Reena, Ludwig Thomas, Lesinski Gregory B, Fernandez Soledad A, Konieczny Stephen F, Leone Gustavo, Wu Jinghai, Ostrowski Michael C

Abstract excerpt

Preclinical studies have suggested that the pancreatic tumor microenvironment both inhibits and promotes tumor development and growth. Here we establish the role of stromal fibroblasts during acinar-to-ductal metaplasia (ADM), an initiating event in pancreatic cancer formation. The transcription factor V-Ets avian erythroblastosis virus E26 oncogene homolog 2 (ETS2) was elevated in smooth muscle actin-positive...

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Identifiers

PMID: 27659014
DOI: 10.1016/j.neo.2016.07.006
PMCID: PMC5031867

Genes

ETS2
ADM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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