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Article

Stromal biology of pancreatic cancer

31 Jan 2007

Abstract excerpt

The genetic paradigm of cancer, focused largely on sequential molecular aberrations and associated biological impact in the neoplastic cell compartment of malignant tumors, has dominated our view of cancer pathogenesis. For the most part, this conceptualization has overlooked the dynamic and complex contributions of the surrounding microenvironment comprised of non-tumor cells (stroma) that may resist, react to,...

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PMID: 17266048
DOI: 10.1002/jcb.21209

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