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Article

SMAD4 and KRAS Status Shapes Cancer Cell-Stromal Cross-Talk and Therapeutic Response in Pancreatic Cancer.

Cancer research - 15 Apr 2025

Lloyd Eloise G, Jihad Muntadher, Manansala Judhell S, Li Wenlong, Cheng Priscilla S W, Mucciolo Gianluca, Zaccaria Marta, Pinto Teles Sara, Araos Henríquez Joaquín, Harish Sneha, Brais Rebecca, Ashworth Sally, Luo Weike, Johnson Paul M, Veghini Lisa, Vallespinos Mireia, Corbo Vincenzo, Biffi Giulia

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) contains an extensive stroma that modulates response to therapy, contributing to the dismal prognosis associated with this cancer. Evidence suggests that PDAC stromal composition is shaped by mutations within malignant cells, but most previous work has focused on preclinical models driven by KrasG12D and mutant Trp53. Elucidation of the contribution of additional known...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 39841099
DOI: 10.1158/0008-5472.CAN-24-2330
PMCID: PMC7617379

Genes

SMAD4
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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