Article

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis

2025-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Inflammation in the pancreas drives acinar-to-ductal metaplasia (ADM), a progenitor-like state that can be hijacked by mutant Kras in the formation of pancreatic cancer (PDAC). How these cell fate decisions vary according to KRAS mutation remains poorly understood. To define mutation-specific lineage reversion and tumor initiation, we implement novel Ptf1a-TdTomato mice and multiple KRAS mutant...

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Literature Corpus work: 69f20acf-2387-53c9-a780-c40af9f4da61
DOI: 10.1101/2025.05.28.656689

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