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Pancreatic Fibroblast Heterogeneity: From Development to Cancer

12 Nov 2020

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is characterized by an extensive fibroinflammatory microenvironment that accumulates from the onset of disease progression. Cancer-associated fibroblasts (CAFs) are a prominent cellular component of the stroma, but their role during carcinogenesis remains controversial, with both tumor-supporting and tumor-restraining functions reported in different studies. One explanation...

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PMID: 33198201
DOI: 10.3390/cells9112464

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