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Article

Sequential infection reprograms the immune landscape to shape future responses

2026-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Mouse models have been instrumental in defining immune mechanisms but often fail to capture the complexity of human immunity, limiting clinical translation. A major limitation is the immunological immaturity of specific pathogen-free (SPF) mice relative to pathogen-experienced adult humans. Here, we use a sequential infection (SI) model that recapitulates cumulative pathogen exposure and define...

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Literature Corpus work
1ef1aa10-49bf-53c5-a439-acff002b3be0
DOI
10.64898/2026.06.26.734836
Open publication

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Sequential infection reprograms the immune landscape to shape future responsesDOI 10.64898/2026.06.26.734836
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