Article

CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells

2026-08-04

Abstract excerpt

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established cohorts) using single-cell RNA sequencing, T cell receptor (TCR) sequencing, and flow cytometry. We identified novel CMV-associated changes i...

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Literature Corpus work: 9c548e59-da50-55a7-8d36-9424695f431d
DOI: 10.1186/s13059-026-04198-5

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