Article
Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection.
Immunity - 13 Jun 2023
Straub Adrian, Grassmann Simon, Jarosch Sebastian, Richter Lena, Hilgendorf Philipp, Hammel Monika, Wagner Karolin I, Buchholz Veit R, Schober Kilian, Busch Dirk H
Abstract excerpt
Repetitive pathogen exposure leads to the dominant outgrowth of T cell clones with high T cell receptor (TCR) affinity to the relevant pathogen-associated antigens. However, low-affinity clones are also known to expand and form immunological memory. While these low-affinity clones contribute less immunity to the original pathogen, their role in protection against pathogens harboring immune escape mutations...
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