Article

Clonally distinct differentiation trajectories shape CD8 <sup>+</sup> memory T cell heterogeneity after acute viral infections in humans

2019-11-07

Abstract excerpt

CD8 + T cells play essential roles in immunity to viral and bacterial infections, and to guard against malignant cells. The CD8 + T cell response to an antigen is composed of many T cell clones with unique T cell receptors, together forming a heterogenous repertoire of phenotypically and functionally distinct effector and memory cells 1, 2 . How individual T cell clones contribute to this heterogeneity during a...

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Literature Corpus work: e09b8628-41b0-595e-af25-cfa98250c71e
DOI: 10.1101/832899

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