Article
Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones.
eLife - 21 Feb 2020
Minervina Anastasia A, Pogorelyy Mikhail V, Komech Ekaterina A, Karnaukhov Vadim K, Bacher Petra, Rosati Elisa, Franke Andre, Chudakov Dmitriy M, Mamedov Ilgar Z, Lebedev Yuri B, Mora Thierry, Walczak Aleksandra M
Abstract excerpt
The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections. Using TCR alpha and beta repertoire sequencing for T-cell subsets, as well as single-cell RNAseq and TCRseq, we track the concentrations and phenotypes of individual T-cell clones in response to primary and secondary yellow fever immunization - the model for acute infection in humans - showing their...
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