Article

Single-cell sequencing reveals clonally expanded plasma cells during chronic viral infection produce virus-specific and cross-reactive antibodies

2021-01-31

Abstract excerpt

Plasma cells and their secreted antibodies play a central role in the long-term protection against chronic viral infection. However, due to experimental limitations, a comprehensive description of linked genotypic, phenotypic, and antibody repertoire features of plasma cells (gene expression, clonal frequency, virus specificity, and affinity) has been challenging to obtain. To address this, we performed single-cel...

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Literature Corpus work: 09a0925d-b57c-5b6f-abf8-2100677138e0
DOI: 10.1101/2021.01.29.428852

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