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Article

ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation.

Nature communications - 4 Feb 2022

Esposito Davide, Pant Ila, Shen Yao, Qiao Rui F, Yang Xiaobao, Bai Yiyang, Jin Jian, Poulikakos Poulikos I, Aaronson Stuart A

Abstract excerpt

Rho family mechano-signaling through the actin cytoskeleton positively regulates physiological TEAD/YAP transcription, while the evolutionarily conserved Hippo tumor suppressor pathway antagonizes this transcription through YAP cytoplasmic localization/degradation. The mechanisms responsible for oncogenic dysregulation of these pathways, their prevalence in tumors, as well as how such dysregulation can be...

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Identifiers

PMID: 35121738
DOI: 10.1038/s41467-022-28319-3
PMCID: PMC8817028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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