Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

YAP/TAZ upstream signals and downstream responses.

Nature cell biology - 1 Aug 2018

Totaro Antonio, Panciera Tito, Piccolo Stefano

Abstract excerpt

Cell behaviour is strongly influenced by physical, mechanical contacts between cells and their extracellular matrix. We review how the transcriptional regulators YAP and TAZ integrate mechanical cues with the response to soluble signals and metabolic pathways to control multiple aspects of cell behaviour, including proliferation, cell plasticity and stemness essential for tissue regeneration. Corruption of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neoplastic Stem Cells
Share to Cell Plasticity
Share to Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanotransduction, Cellular

Share to Phosphoproteins

Share to Stem Cells

Share to Stress, Mechanical

Share to YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 30050119
DOI: 10.1038/s41556-018-0142-z
PMCID: PMC6186418

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

YAP/TAZ upstream signals and downstream responses.PMID 30050119Read ↗

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.Semantic proximity Read ↗

Single-cell transcriptome analysis revealing mechanotransduction via the Hippo/YAP pathway in promoting fibroblast-to-myofibroblast transition and idiopathic pulmonary fibrosis developmentSemantic proximity Read ↗

Mechano-epigenetic regulation of extracellular matrix homeostasis via Yap and TazSemantic proximity Read ↗

Mechano-signaling of prostate tumor initiating cells facilitates their tropism to stiff metastatic nicheSemantic proximity Read ↗

Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransductionSemantic proximity Read ↗

Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and DifferentiationSemantic proximity Read ↗

Mechanoepigenetic regulation of extracellular matrix homeostasis via Yap and TazSemantic proximity Read ↗

YAP/TAZ: Key Players for Rheumatoid Arthritis Severity by Driving Fibroblast Like Synoviocytes Phenotype and Fibro-Inflammatory Response.Semantic proximity Read ↗

YAP-mediated mechanotransduction tunes the macrophage inflammatory responseSemantic proximity Read ↗

ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation.Semantic proximity Read ↗

YAP-independent mechanotransduction drives breast cancer progressionSemantic proximity Read ↗

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased FibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.