Article

An integrative oncogene-dependency map identifies unique vulnerabilities of oncogenic EGFR, KRAS, and RIT1 in lung cancer

2020-07-04

Abstract excerpt

<h4>ABSTRACT</h4> Advances in precision oncology have transformed cancer therapy from broadly-applied cytotoxic therapy to personalized treatments based on each tumor’s unique molecular alterations. Here we investigate the oncogene-specific dependencies conferred by lung cancer driver variants of KRAS, EGFR , and RIT1 . Integrative analysis of genome-wide CRISPR screens in isogenic cell lines identified shared...

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Literature Corpus work: 2f87b3b1-19fa-5bce-8859-d500be2cc221
DOI: 10.1101/2020.07.03.187310

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