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Article

Activating ROCK1 somatic mutations in human cancer.

Oncogene - 29 Apr 2010

Lochhead P A, Wickman G, Mezna M, Olson M F

Abstract excerpt

Cancer cells acquire characteristics of deregulated growth, survival and increased metastatic potential. Genetic mutations that provide a selective advantage by promoting these characteristics have been termed 'drivers,' whereas mutations that do not contribute to disease initiation/progression are termed 'passengers.' The advent of high-throughput methodologies has facilitated large-scale screening of cancer...

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Identifiers

PMID: 20140017
DOI: 10.1038/onc.2010.3

Genes

ROCK1

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