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Targeting ROCK signaling in health, malignant and non-malignant diseases.

Immunology letters - 1 Mar 2020

Shahbazi Roya, Baradaran Behzad, Khordadmehr Monireh, Safaei Sahar, Baghbanzadeh Amir, Jigari Farinaz, Ezzati Hamed

Abstract excerpt

A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) and ROCK2 (also known as Rho-kinase and ROKα), the gene of which is placed on chromosomes 18 (18q11.1) and 2 (2p24), respectively. ROCKs have a principal function in the generation of actin-myosin contractility and regulation of actin...

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PMID: 31904392
DOI: 10.1016/j.imlet.2019.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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