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Rho, ROCK and actomyosin contractility in metastasis as drug targets

29 Apr 2016

Abstract excerpt

Metastasis is the spread of cancer cells around the body and the cause of the majority of cancer deaths. Metastasis is a very complex process in which cancer cells need to dramatically modify their cytoskeleton and cope with different environments to successfully colonize a secondary organ. In this review, we discuss recent findings pointing at Rho-ROCK or actomyosin force (or both) as major drivers of many of...

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PMID: 27158478
DOI: 10.12688/f1000research.7909.1

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