Article
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.
Nature communications - 9 Aug 2021
Vichas Athea, Riley Amanda K, Nkinsi Naomi T, Kamlapurkar Shriya, Parrish Phoebe C R, Lo April, Duke Fujiko, Chen Jennifer, Fung Iris, Watson Jacqueline, Rees Matthew, Gabel Austin M, Thomas James D, Bradley Robert K, Lee John K, Hatch Emily M, Baine Marina K, Rekhtman Natasha, Ladanyi Marc, Piccioni Federica, Berger Alice H
Abstract excerpt
CRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common oncogenes. To identify opportunities for therapeutic intervention in other rarer subsets of cancer, we investigate the oncogene-specific dependencies conferred by the lung cancer oncogene, RIT1. Here, genome-wide CRISPR screening in KRAS, EGFR, and RIT1-mutant...
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