Article
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
American journal of physiology. Lung cellular and molecular physiology - 15 Feb 2015
Liu Fei, Lagares David, Choi Kyoung Moo, Stopfer Lauren, Marinković Aleksandar, Vrbanac Vladimir, Probst Clemens K, Hiemer Samantha E, Sisson Thomas H, Horowitz Jeffrey C, Rosas Ivan O, Fredenburgh Laura E, Feghali-Bostwick Carol, Varelas Xaralabos, Tager Andrew M, Tschumperlin Daniel J
Abstract excerpt
Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation. However, the molecular mechanisms underlying this process remain poorly understood. Here we identify yes-associated protein (YAP) (homolog of drosophila Yki) and transcriptional coactivator with PDZ-binding motif (TAZ) (also known as Wwtr1), transcriptional...
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