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Article

The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy.

Science China. Life sciences - 1 Aug 2024

Zhang Peidong, Li Peiwei, Tang Muya, Gimple Ryan C, Huang Liang, Yue Jing, Shen Qiuhong, Du Yiwei, Zhang Qian, Yang Zhengnan, He Haihuai, Yang Kailin, Zhao Linjie, Zhou Shengtao

Abstract excerpt

Mechanics shape cell and tissue plasticity and maintain their homeostasis. In cancers, mechanical signals regulate cancer hallmarks via mechanotransduction pathways, such as proliferation, metastasis and metabolic reprogramming. However, comprehensive characterization of mechanotransduction pathway genes and their clinical relevance across different cancer types remains untouched. Herein, we systematically...

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PMID: 39037695
DOI: 10.1007/s11427-024-2622-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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