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Article

Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19.

Translational research : the journal of laboratory and clinical medicine - 1 Jun 2022

Nln Ilona, Fernandez-Ruiz Ruth, Muskardin Theresa L Wampler, Paredes Jacqueline L, Blazer Ashira D, Tuminello Stephanie, Attur Mukundan, Iturrate Eduardo, Petrilli Christopher M, Abramson Steven B, Chakravarti Aravinda, Niewold Timothy B

Abstract excerpt

Type I interferon (IFN) is critical in our defense against viral infections. Increased type I IFN pathway activation is a genetic risk factor for systemic lupus erythematosus (SLE), and a number of common risk alleles contribute to the high IFN trait. We hypothesized that these common gain-of-function IFN pathway alleles may be associated with protection from mortality in acute COVID-19. We studied patients...

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Identifiers

PMID: 35114420
DOI: 10.1016/j.trsl.2022.01.007
PMCID: PMC8802623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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