A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.

doi:10.1038/ng1782

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Article

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.

Nature genetics - 1 May 2006

Graham Robert R, Kozyrev Sergey V, Baechler Emily C, Reddy M V Prasad Linga, Plenge Robert M, Bauer Jason W, Ortmann Ward A, Koeuth Thearith, González Escribano Ma Francisca, Pons-Estel Bernardo, Petri Michelle, Daly Mark, Gregersen Peter K, Martín Javier, Altshuler David, Behrens Timothy W, Alarcón-Riquelme Marta E

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by activation of the type I interferon (IFN) pathway. Here we convincingly replicate association of the IFN regulatory factor 5 (IRF5) rs2004640 T allele with SLE in four independent case-control cohorts (P = 4.4 x 1...

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PMID: 16642019
DOI: 10.1038/ng1782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16642019-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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