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Article

Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions.

Journal of biomedicine & biotechnology - 1 Jan 2012

Guthridge Joel M, Clark Daniel N, Templeton Amanda, Dominguez Nicolas, Lu Rufei, Vidal Gabriel S, Kelly Jennifer A, Kauffman Kenneth M, Harley John B, Gaffney Patrick M, James Judith A, Poole Brian D

Abstract excerpt

Both genetic and environmental interactions affect systemic lupus erythematosus (SLE) development and pathogenesis. One known genetic factor associated with lupus is a haplotype of the interferon regulatory factor 5 (IRF5) gene. Analysis of global gene expression microarray data using gene set enrichment analysis identified multiple interferon- and inflammation-related gene sets significantly overrepresented in...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22500098
DOI: 10.1155/2012/594056
PMCID: PMC3304673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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