Article

Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19

2021-11-02

Abstract excerpt

Type I interferon (IFN) is critical in our defense against viral infections. Increased type I IFN pathway activation is a genetic risk factor for systemic lupus erythematosus (SLE), and a number of common risk alleles contribute to the high IFN trait. We hypothesized that these common gain-of-function IFN pathway alleles may be associated with protection from mortality in acute COVID-19. We studied patients admitt...

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Literature Corpus work: 13fa64a0-2619-5bff-8b09-44b9953180ed
DOI: 10.1101/2021.11.01.21265766

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