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Article

Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.

Genes and immunity - 1 Jan 2000

Kariuki S N, Ghodke-Puranik Y, Dorschner J M, Chrabot B S, Kelly J A, Tsao B P, Kimberly R P, Alarcón-Riquelme M E, Jacob C O, Criswell L A, Sivils K L, Langefeld C D, Harley J B, Skol A D, Niewold T B

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by inflammation of multiple organ systems and dysregulated interferon responses. SLE is both genetically and phenotypically heterogeneous, greatly reducing the power of case-control studies in SLE. Elevated circulat...

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Source

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Identifiers

PMID: 25338677
DOI: 10.1038/gene.2014.57
PMCID: PMC4305028

Genes

PLEKHF2
PNP
PRKG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-25338677-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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