Article
Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans.
Genes and immunity - 1 Apr 2008
Kelly J A, Kelley J M, Kaufman K M, Kilpatrick J, Bruner G R, Merrill J T, James J A, Frank S G, Reams E, Brown E E, Gibson A W, Marion M C, Langefeld C D, Li Q-Z, Karp D R, Wakeland E K, Petri M, Ramsey-Goldman R, Reveille J D, Vilá L M, Alarcón G S, Kimberly R P, Harley J B, Edberg J C
Abstract excerpt
Increased expression of interferon (IFN)-inducible genes is implicated in the pathogenesis of systemic lupus erythematosus (SLE). One transcription factor responsible for regulating IFN, interferon regulatory factor-5 (IRF5), has been associated with SLE in genetic studies of Asian, Caucasian and Hispanic populations. We genotyped up to seven polymorphic loci in or near IRF5 in a total of 4870 African-American...
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