Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

doi:10.1073/pnas.0701266104

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Article

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2007

Graham Robert R, Kyogoku Chieko, Sigurdsson Snaevar, Vlasova Irina A, Davies Leela R L, Baechler Emily C, Plenge Robert M, Koeuth Thearith, Ortmann Ward A, Hom Geoffrey, Bauer Jason W, Gillett Clarence, Burtt Noel, Cunninghame Graham Deborah S, Onofrio Robert, Petri Michelle, Gunnarsson Iva, Svenungsson Elisabet, Rönnblom Lars, Nordmark Gunnel, Gregersen Peter K, Moser Kathy, Gaffney Patrick M, Criswell Lindsey A, Vyse Timothy J, Syvänen Ann-Christine, Bohjanen Paul R, Daly Mark J, Behrens Timothy W, Altshuler David

Abstract excerpt

Systematic genome-wide studies to map genomic regions associated with human diseases are becoming more practical. Increasingly, efforts will be focused on the identification of the specific functional variants responsible for the disease. The challenges of identifying causal variants include the...

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Identifiers

PMID: 17412832
DOI: 10.1073/pnas.0701266104
PMCID: PMC1847749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17412832-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

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