Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential regulation of the interferon response in systemic lupus erythematosus distinguishes patients of Asian ancestry.

RMD open - 1 Sept 2023

Rector Ian, Owen Katherine A, Bachali Prathyusha, Hubbard Erika, Yazdany Jinoos, Dall'era Maria, Grammer Amrie C, Lipsky Peter E

Abstract excerpt

OBJECTIVES: Type I interferon (IFN) plays a role in the pathogenesis of systemic lupus erythematosus (SLE), but insufficient attention has been directed to the differences in IFN responses between ancestral populations. Here, we explored the expression of the interferon gene signatures (IGSs) in SLE patients of European ancestry (EA) and Asian ancestry (AsA). METHODS: We used gene set variation analysis with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Type I

Share to Killer Cells, Natural

Share to Lupus Erythematosus, Systemic

Source

Open in PubMed Open full text

Identifiers

PMID: 37709528
DOI: 10.1136/rmdopen-2023-003475
PMCID: PMC10503349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential regulation of the interferon response in systemic lupus erythematosus distinguishes patients of Asian ancestry.PMID 37709528Read ↗

A Comprehensive Analysis of Type I Interferon Risk Gene Signatures in Systemic Lupus Erythematosus.Semantic proximity Read ↗

Type I interferon gene signature test–low and –high patients with systemic lupus erythematosus have distinct gene expression signaturesSemantic proximity Read ↗

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosusSemantic proximity Read ↗

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosusSemantic proximity Read ↗

Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromesSemantic proximity Read ↗

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupusSemantic proximity Read ↗

Optimal Selection of IFN-α-Inducible Genes to Determine Type I Interferon Signature Improves the Diagnosis of Systemic Lupus ErythematosusSemantic proximity Read ↗

Single-cell RNA-seq reveals a persistent interferon signature in immune cells from Systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatmentSemantic proximity Read ↗

Type I Interferon Signature Strength Correlates with Alloimmunization-Associated Transcriptomic Programs in Systemic Lupus Erythematosus: A Multi-Cohort AnalysisSemantic proximity Read ↗

Ethnicity-specific transcriptomic variation in immune cells and correlation with disease activity in systemic lupus erythematosusSemantic proximity Read ↗

Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: Identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAISemantic proximity Read ↗

The genetics of type I interferon in systemic lupus erythematosus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.