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Article

IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE.

JCI insight - 30 Jan 2020

Li Dan, Matta Bharati, Song Su, Nelson Victoria, Diggins Kirsten, Simpfendorfer Kim R, Gregersen Peter K, Linsley Peter, Barnes Betsy J

Abstract excerpt

Genetic variants within or near the interferon regulatory factor 5 (IRF5) locus associate with systemic lupus erythematosus (SLE) across ancestral groups. The major IRF5-SLE risk haplotype is common across populations, yet immune functions for the risk haplotype are undefined. We characterized the global immune phenotype of healthy donors homozygous for the major risk and nonrisk haplotypes and identified cell...

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Identifiers

PMID: 31877114
DOI: 10.1172/jci.insight.124020
PMCID: PMC7098722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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