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Article

Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity.

Genes and immunity - 1 Dec 2016

Bearoff F, Del Rio R, Case L K, Dragon J A, Nguyen-Vu T, Lin C-Y, Blankenhorn E P, Teuscher C, Krementsov D N

Abstract excerpt

Regulation of gene expression in immune cells is known to be under genetic control, and likely contributes to susceptibility to autoimmune diseases such as multiple sclerosis (MS). How this occurs in concert across multiple immune cell types is poorly understood. Using a mouse model that harnesses the genetic diversity of wild-derived mice, more accurately reflecting genetically diverse human populations, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

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Identifiers

PMID: 27653816
DOI: 10.1038/gene.2016.37
PMCID: PMC5133152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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