Article

OCA-B promotes pathogenic maturation of stem-like CD4 <sup>+</sup> T cells and autoimmune demyelination

2023-11-30

Abstract excerpt

Stem-like T cells selectively contribute to autoimmunity, but the activities that promote their pathogenicity are incompletely understood. Here, we identify the transcription coregulator OCA-B as a driver of the pathogenic maturation of stem-like CD4 + T cell to promote autoimmune demyelination. Using two human multiple sclerosis (MS) datasets, we show that POU2AF1 , the gene encoding OCA-B, is elevated in CD4...

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Literature Corpus work: 3089230b-24a2-57a0-9840-eac96a0e6822
DOI: 10.1101/2023.11.29.569210

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