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GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate

11 Mar 2022

Abstract excerpt

GATA4/5/6 transcription factors play essential, conserved roles in heart development. To understand how GATA4/5/6 modulates the mesoderm-to-cardiac fate transition, we labeled, isolated, and performed single-cell gene expression analysis on cells that express gata5 at precardiac time points spanning zebrafish gastrulation to somitogenesis. We found that most mesendoderm-derived lineages had dynamic gata5/6...

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PMID: 35275720
DOI: 10.1126/sciadv.abg0834

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