Article

Torsion of the heart tube by shortage of progenitor cells : identification of <i>Greb1l</i> as a genetic determinant of criss-cross hearts in mice

2023-05-11

Abstract excerpt

<h4>Summary</h4> Despite their burden and impact, most congenital defects remain poorly understood by lack of knowledge of the embryological mechanisms. Here, we identify Greb1l mutants as the first mouse model of criss-cross heart. Based on 3D quantifications of shape changes, we demonstrate that torsion of the atrioventricular canal occurs together with supero-inferior ventricles at E10.5, after heart looping....

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Literature Corpus work: 3114ab00-2d7a-5ca2-96a9-893324971576
DOI: 10.1101/2023.05.11.540418

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