Article

Hierarchical TBX6-FOXC Regulatory Logic Governs Human Trunk Mesoderm Diversification

2026-03-18

Abstract excerpt

<h4>Summary</h4> Mesoderm forms during gastrulation and diversifies to generate many embryonic tissues, yet the regulatory logic governing early human mesodermal lineage decisions remains poorly defined. We use human iPSC-derived 3D trunk-like structures (hTLS) to model lineage specification during early post-gastrulation development, a stage experimentally inaccessible in humans. Developing hTLS generate neural...

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Literature Corpus work: 1a5d4790-812f-5a27-8e96-1414ab802757
DOI: 10.64898/2026.03.17.712295

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