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Article

Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction

24 Jul 2018

Abstract excerpt

ABSTRACT A small network of spontaneously active Tbx3+ cardiomyocytes forms the cardiac conduction system (CCS) in adults. Understanding the origin and mechanism of development of the CCS network are important steps towards disease modeling and the development of biological pacemakers to treat arrhythmias. We found that Tbx3 expression in the embryonic mouse heart is associated with automaticity. Genetic...

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Share to Cardiac electrophysiology and arrhythmias
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Share to Congenital heart defects research

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PMID: 30042181
DOI: 10.1242/dev.167361

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