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Article

Introduction of Somatic Mutation in MED12 Induces Wnt4/β-Catenin and Disrupts Autophagy in Human Uterine Myometrial Cell.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Mar 2020

El Andaloussi Abdeljabar, Al-Hendy Ayman, Ismail Nahed, Boyer Thomas G, Halder Sunil K

Abstract excerpt

Uterine fibroids (UFs) or leiomyoma are frequently associated with somatic mutations in the mediator complex subunit 12 (MED12) gene; however, the function of these mutations in human UF biology is yet to be determined. Herein, we determined the functional role of the most common MED12 somatic mutation in the modulation of oncogenic Wnt4/β-catenin and mammalian target of rapamycin (mTOR) signaling pathways. Using...

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Identifiers

PMID: 32046450
DOI: 10.1007/s43032-019-00084-7
PMCID: PMC7539814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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