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Article

Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation.

Cancer discovery - 1 Nov 2016

Akıncılar Semih Can, Khattar Ekta, Boon Priscilla Li Shan, Unal Bilal, Fullwood Melissa Jane, Tergaonkar Vinay

Abstract excerpt

Cancer-specific TERT promoter mutations (-146C>T and -124C>T) have been linked to reactivation of the epigenetically silenced telomerase reverse transcriptase gene (TERT). Understanding how these single-nucleotide alterations drive TERT reactivation is a fundamental unanswered question and is key for making successful therapeutics. We show that unlike wild-type promoters, recruitment of the transcription factor...

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Topics

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Share to Cell Line, Tumor
Share to Chromatin
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Promoter Regions, Genetic

Share to Telomerase

Share to Transcriptional Activation

Source

Identifiers

PMID: 27650951
DOI: 10.1158/2159-8290.CD-16-0177

Genes

TERT
GABPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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