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Article

MED12 dysregulation: insights into cancer and therapeutic resistance.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Aug 2025

Bhole Ritesh, Shinkar Jagruti, Labhade Sonali, Karwa Pawan, Kapare Harshad

Abstract excerpt

MED12, a critical subunit of the mediator (MED) complex, plays a central role in transcriptional regulation by bridging signal-dependent transcription factors and RNA polymerase II. Dysregulation of MED12, often through mutation, has emerged as a significant driver in various cancers, including uterine leiomyomas, breast cancer (B.C.), and prostate cancer (P.C.). These mutations disrupt normal transcriptional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40105922
DOI: 10.1007/s00210-025-04006-0

Genes

MED12
ALK
BRAF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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