Article
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.
Nature - 10 Sept 2015
Zhu Jiajun, Sammons Morgan A, Donahue Greg, Dou Zhixun, Vedadi Masoud, Getlik Matthäus, Barsyte-Lovejoy Dalia, Al-awar Rima, Katona Bryson W, Shilatifard Ali, Huang Jing, Hua Xianxin, Arrowsmith Cheryl H, Berger Shelley L
Abstract excerpt
TP53 (which encodes p53 protein) is the most frequently mutated gene among all human cancers. Prevalent p53 missense mutations abrogate its tumour suppressive function and lead to a 'gain-of-function' (GOF) that promotes cancer. Here we show that p53 GOF mutants bind to and upregulate chromatin regulatory genes, including the methyltransferases MLL1 (also known as KMT2A), MLL2 (also known as KMT2D), and...
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