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Article

Dual roles of c-Myc in the regulation of hTERT gene

28 Aug 2014

Abstract excerpt

Human telomerase gene hTERT is important for cancer and aging. hTERT promoter is regulated by multiple transcription factors (TFs) and its activity is dependent on the chromatin environment. However, it remains unsolved how the interplay between TFs and chromatin environment controls hTERT transcription. In this study, we employed the recombinase-mediated BAC targeting and BAC recombineering techniques to dissect...

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Share to Advanced biosensing and bioanalysis techniques
Share to Genomics and Chromatin Dynamics
Share to Telomeres, Telomerase, and Senescence

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PMID: 25170084
DOI: 10.1093/nar/gku721

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Dual roles of c-Myc in the regulation of hTERT genePMID 25170084Read ↗

Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).Semantic proximity Read ↗

Human Telomerase Reverse Transcriptase (hTERT) Transcription Requires Sp1/Sp3 Binding to the Promoter and a Permissive Chromatin EnvironmentSemantic proximity Read ↗

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Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYCSemantic proximity Read ↗

Understanding and exploiting <i>hTERT</i> promoter regulation for diagnosis and treatment of human cancersSemantic proximity Read ↗

A modular open platform for systematic functional studies under physiological conditions.Semantic proximity Read ↗

Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc.Semantic proximity Read ↗

Rearrangement of upstream sequences of the hTERT gene during cellular immortalization.Semantic proximity Read ↗

hTERT promotes cell adhesion and migration independent of telomerase activity.Semantic proximity Read ↗

Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase.Semantic proximity Read ↗

Epidermal growth factor activates telomerase activity by direct binding of Ets-2 to hTERT promoter in lung cancer cells.Semantic proximity Read ↗

BRG1, the ATPase subunit of SWI/SNF chromatin remodeling complex, interacts with HDAC2 to modulate telomerase expression in human cancer cellsSemantic proximity Read ↗

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