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Article

Estimating prevalence of human traits among populations from polygenic risk scores.

Human genomics - 13 Dec 2021

Graham Britney E, Plotkin Brian, Muglia Louis, Moore Jason H, Williams Scott M

Abstract excerpt

The genetic basis of phenotypic variation across populations has not been well explained for most traits. Several factors may cause disparities, from variation in environments to divergent population genetic structure. We hypothesized that a population-level polygenic risk score (PRS) can explain phenotypic variation among geographic populations based solely on risk allele frequencies. We applied a...

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Identifiers

PMID: 34903281
DOI: 10.1186/s40246-021-00370-z
PMCID: PMC8670062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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