Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pragmatic Approach to Applying Polygenic Risk Scores to Diverse Populations.

Current protocols - 1 Nov 2023

Patel Aniruddh P, Fahed Akl C

Abstract excerpt

Polygenic risk scores (PRS) estimate genetic susceptibility of an individual to disease and have the potential of providing utility in multiple clinical contexts. However, their performance, computation, and reporting in diverse populations remain challenging. Here, we present a pragmatic approach to optimize a PRS for a population of interest that leverages publicly available data and methods and consists of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study
Share to Multifactorial Inheritance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 37921506
DOI: 10.1002/cpz1.911
PMCID: PMC11196001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pragmatic Approach to Applying Polygenic Risk Scores to Diverse Populations.PMID 37921506Read ↗

S4-Multi: enhancing polygenic score prediction in ancestrally diverse populationsSemantic proximity Read ↗

Polygenic Risk Scores in Human Disease.Semantic proximity Read ↗

PGS Browser: a public platform for personalized polygenic score analysis and interpretation.Semantic proximity Read ↗

Recent advances in polygenic scores: translation, equitability, methods and FAIR tools.Semantic proximity Read ↗

Admixture-informed polygenic risk reporting using the ePRS framework.Semantic proximity Read ↗

Principles and methods for transferring polygenic risk scores across global populations.Semantic proximity Read ↗

Advancements and limitations in polygenic risk score methods for genomic prediction: a scoping review.Semantic proximity Read ↗

Challenges and Opportunities for Developing More Generalizable Polygenic Risk Scores.Semantic proximity Read ↗

Polygenic risk scores: from research tools to clinical instruments.Semantic proximity Read ↗

Improving reporting standards for polygenic scores in risk prediction studies.Semantic proximity Read ↗

From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer.Semantic proximity Read ↗

Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score CatalogSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.