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Modification effect of polygenic risk scores on the risk of the most common multimorbidity associated with aging among Canadian adults: An analysis of the CLSA data.

Archives of gerontology and geriatrics - 1 Nov 2025

Mortey Obed, Mugford Gerald, Aubrey-Bassler Kris, Mariathas Hensley H, Odimba Ugochukwu, Gao Zhiwei

Abstract excerpt

OBJECTIVE: We investigated the modification effects of polygenic risk score (PRS) on the risk of the most common multimorbidity (MCM) in Canadian adults associated with aging. METHODS: We utilized baseline and genomic datasets of 26,622 adults aged 45-85 years from the Canadian Longitudinal Study on Aging. Genome-wide interaction analyses and multivariate logistic regression models were used to identify...

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PMID: 40845754
DOI: 10.1016/j.archger.2025.105992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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