Polygenic risk scores in human genetics for study design discovery and translation.

Abstract excerpt

Polygenic risk scores (PRS) quantify the component of disease risk captured by measured additive common variants. Their use as a study design variable, rather than only as a predictive endpoint, broadens their scientific value in human genetics. PRS can define informative extremes of common-variant burden, identify discordance between phenotype and PRS-estimated risk, and facilitate the detection of...

Topics

• Humans
• Genetic Risk Score
• Genome-Wide Association Study
• Multifactorial Inheritance
• Genetic Predisposition to Disease
• Phenotype
• Research Design