Article
Can polygenic risk scores help explain disease prevalence differences around the world? A worldwide investigation.
BMC genomic data - 20 Nov 2023
Jain Pritesh R, Burch Myson, Martinez Melanie, Mir Pablo, Fichna Jakub P, Zekanowski Cezary, Rizzo Renata, Tümer Zeynep, Barta Csaba, Yannaki Evangelia, Stamatoyannopoulos John, Drineas Petros, Paschou Peristera
Abstract excerpt
Complex disorders are caused by a combination of genetic, environmental and lifestyle factors, and their prevalence can vary greatly across different populations. The extent to which genetic risk, as identified by Genome Wide Association Study (GWAS), correlates to disease prevalence in different populations has not been investigated systematically. Here, we studied 14 different complex disorders and explored...
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