Article
Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study.
European journal of human genetics : EJHG - 1 Jun 2017
Nolte Ilja M, van der Most Peter J, Alizadeh Behrooz Z, de Bakker Paul Iw, Boezen H Marike, Bruinenberg Marcel, Franke Lude, van der Harst Pim, Navis Gerjan, Postma Dirkje S, Rots Marianne G, Stolk Ronald P, Swertz Morris A, Wolffenbuttel Bruce Hr, Wijmenga Cisca, Snieder Harold
Abstract excerpt
Despite the recent explosive rise in number of genetic markers for complex disease traits identified in genome-wide association studies, there is still a large gap between the known heritability of these traits and the part explained by these markers. To gauge whether this 'heritability gap' is closing, we first identified genome-wide significant SNPs from the literature and performed replication analyses for 32...
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