Article
Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research.
American journal of human genetics - 2 Apr 2026
Cromer Sara J, Cobran Ewan K, Iyer Hari S, Hysong Micah R, Vargas Luciana B, Smith Johanna L, Konigsberg Iain R, Bogumil David, Glover LáShauntá, King Gillian, Lange Leslie A, Patel Aniruddh, Wojcik Genevieve, Raffield Laura, Conti David V
Abstract excerpt
There is a growing interest in evaluating the intersection of genetic and environmental factors, particularly social determinants of health (SDoH). As both the distributions and associations of genetic and SDoH-related risk vary across populations, a thorough understanding of the interplay of these factors (genetics and SDoH across populations) is necessary for the appropriate design and interpretation of studies...
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