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Article

Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas.

International journal of molecular sciences - 1 Dec 2021

Sepulveda-Yanez Julieta H, Alvarez-Saravia Diego, Fernandez-Goycoolea Jose, Aldridge Jacqueline, van Bergen Cornelis A M, Posthuma Ward, Uribe-Paredes Roberto, Veelken Hendrik, Navarrete Marcelo A

Abstract excerpt

Activation-induced deaminase (AID) is required for somatic hypermutation in immunoglobulin genes, but also induces off-target mutations. Follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL), the most frequent types of indolent B-cell tumors, are exposed to AID activity during lymphomagenesis. We designed a workflow integrating de novo mutational signatures extraction and fitting of COSMIC (Catalogue Of...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34884820
DOI: 10.3390/ijms222313015
PMCID: PMC8657711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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