Article
Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution.
Nature communications - 7 Dec 2015
Kasar S, Kim J, Improgo R, Tiao G, Polak P, Haradhvala N, Lawrence M S, Kiezun A, Fernandes S M, Bahl S, Sougnez C, Gabriel S, Lander E S, Kim H T, Getz G, Brown J R
Abstract excerpt
Patients with chromosome 13q deletion or normal cytogenetics represent the majority of chronic lymphocytic leukaemia (CLL) cases, yet have relatively few driver mutations. To better understand their genomic landscape, here we perform whole-genome sequencing on a cohort of patients enriched with these cytogenetic characteristics. Mutations in known CLL drivers are seen in only 33% of this cohort, and associated...
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