Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers.

Scientific reports - 7 Dec 2016

Rogozin Igor B, Lada Artem G, Goncearenco Alexander, Green Michael R, De Subhajyoti, Nudelman German, Panchenko Anna R, Koonin Eugene V, Pavlov Youri I

Abstract excerpt

Follicular lymphoma (FL) is an uncurable cancer characterized by progressive severity of relapses. We analyzed sequence context specificity of mutations in the B cells from a large cohort of FL patients. We revealed substantial excess of mutations within a novel hybrid nucleotide motif: the signature of somatic hypermutation (SHM) enzyme, Activation Induced Deaminase (AID), which overlaps the CpG methylation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Cytosine

Share to DNA Methylation

Share to Lymphoma, Follicular

Share to Mutagenesis

Share to Nucleotides

Source

Open in PubMed Open full text

Identifiers

PMID: 27924834
DOI: 10.1038/srep38133
PMCID: PMC5141443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers.PMID 27924834Read ↗

A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets.Semantic proximity Read ↗

High-risk follicular lymphomas harbour more somatic mutations including those in the AID-motif.Semantic proximity Read ↗

Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas.Semantic proximity Read ↗

Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas.Semantic proximity Read ↗

Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FLSemantic proximity Read ↗

Role of activation-induced cytidine deaminase (AID) in follicular lymphoma biologySemantic proximity Read ↗

Somatic hypermutation mechanisms during lymphomagenesis and transformation.Semantic proximity Read ↗

AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.Semantic proximity Read ↗

Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.Semantic proximity Read ↗

Intraclonal diversity in follicular lymphoma analyzed by quantitative ultradeep sequencing of noncoding regions.Semantic proximity Read ↗

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.Semantic proximity Read ↗

Genome-wide somatic hypermutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.